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Your Health, Our Success!

The Japanese media frequently claim, especially in television shows for health-concerned viewers, that nattō is health-enhancing and that these claims are backed by medical research.

Medicinal isolates of nattō include pyrazine and tetramethylpyrazine. Pyrazine is a compound that, in addition to giving nattō its distinct smell, reduces the likelihood ofblood clotting. It also contains a serine protease type enzyme called nattokinase which also may reduce blood clotting both by direct fibrinolysis of clots, and inhibition of the plasma protein plasminogen activator inhibitor 1. This may help to avoid thrombosis, as for example in heart attacks, pulmonary embolism, or strokes.

An extract from nattō containing nattokinase is available as a dietary supplement. Studies have shown that oral administration of nattokinase in enteric capsules leads to a mild enhancement of fibrinolytic activity in rats and dogs. It is, therefore, plausible to hypothesize that nattokinase might reduce blood clots in humans—although clinical trials have not been conducted. Another study suggests that Fibrinolysis Accelerating Substance (FAS) in natto is the substance which initiates fibrinolysis of clots, which accelerates the activity of not only nattokinase, but urokinase.

A 2009 study in Taiwan indicated that the nattokinase in natto has the ability to degrade amyloid fibrils, suggesting that it might be a preventative or a treatment for amyloid-type diseases such as Alzheimer's.

Natto is rich in vitamin K. It contains large amounts of vitamin K₂, which is involved in the formation of calcium-binding groups in proteins, assisting the formation of bone and preventing osteoporosis. Vitamin K₁ is found naturally in leafy greens, seaweed, liver, and some vegetables, while vitamin K₂ (Menatetrenone) is found in fermented food products such as cheese, miso, and Nattō.

According to a study, fermented soybeans, such as nattō, contain vitamin PQQ, which is important for the skin. PQQ in human tissues is derived mainly from diet.

According to recent studies, polyamine suppresses excessive immune reactions, and nattō has a much larger amount of it than any other food. Dietary supplements containing the substances extracted from natto such as polyamine, nattokinase, FAS, and vitamin K₂ are available.

Nattō contains chemicals alleged to prevent cancer, for example, daidzein, genistein, isoflavone, phytoestrogen, and the chemical element selenium, however, most of these chemicals also may be found in other soybean products, and their effect on cancer prevention is uncertain.

Recent studies show nattō may have a cholesterol-lowering effect.

Nattō's use as medicine against dysentery was researched by the Imperial Japanese Navy before World War II.

Nattō is also sometimes used as an ingredient of pet food, and it is claimed that this improves the health of the pets.