Malathion lotion is used to treat head lice (small insects that attach themselves to the skin) in adults and children 6 years of age and older. It should not be used in infants and children younger than 2 years of age. Malathion is in a class of medications called pediculicides. It works by killing lice.

Malathion comes as a lotion to apply to the scalp and hair. It is usually applied to the scalp and hair in one or sometimes two treatments. If live lice are seen 7 to 9 days after the first treatment then apply a second treatment of malathion lotion. Follow the directions on your prescription label or the package label carefully.