Indole-3-carbinol (I3C) is a compound found in high concentrations in vegetables of the Brassica family including broccoli cauliflower Brussels sprouts and cabbage.
As a dietary supplement I3C provides key nutritional support for liver detoxification. It also plays an important role in supporting female reproductive health. The majority of ingested I3C is absorbed in the small intestine as diindolylmethane (DIM) which is thought to be the primary contributor to I3C's beneficial properties. DIM has been shown to selectively bind to estrogen receptors and may act as an estrogen antagonist at physiological concentration.
In the liver I3C promotes the metabolism of estrogen and increases the ratio of 2-hydroxy estrogen to 16-hydroxy estrogen. The 2-hydroxy estrogens less active than the 16-hydroxy estrogens generally are eliminated more rapidly from the body. One prospective study found postmenopausal women with the most favorable urinary 2:16-hydroxyestrone ratio were most likely to maintain good female health.
Preliminary studies have examined the efficacy safety and optimal supplementation of I3C. A 12-week phase I trial conducted on 17 women found a 66-percent increase in urinary 2:16-hydroxyestrone ratio with administration of 400 mg I3C daily.
Suggested Use
Take 1 capsule one to two times daily or as recommended by your health-care practitioner.
Other Ingredients
Hypromellose (derived from cellulose) capsule microcrystalline cellulose leucine silicon dioxide.
Warnings
Tamper Evident: Use only if bottle is sealed.
If pregnant consult your health-care practitioner before using this product.
Store tightly sealed in a cool dry place.