- System: Android 7.0 Nougat with HTC Sense
- Processor: 2.15 GHz (2x2.15 GHz Kryo & 2x1.6 GHz Kryo) / Quad Core / Qualcomm MSM8996 Snapdragon 821
- GPU: Adreno 530
- Memory: ROM: 64 GB / RAM: 4 GB / Slot type: microSD / Max. slot capacity: 2 TB
- Display: 5.7" / Quad HD / Resolution: 2560 x 1440 pixels, 513 ppi / Dual Display: 2.05", 1040 x 160 pixels
- Camera:
Main/Rear: 12 MP / f/1.8 OIS / Laser & phase detection autofocus / Flash: Dual Tone LED / BSI1/2.3'' sensor size, 1.55µm pixel size, geo-tagging, touch focus, face detection, Auto-HDR, panorama
Front: 16 MP / 1080p / Auto-HDR
Video: 4K Ultra HD (2160p@30fps (24-bit/192kHz audio) / Slow motion: 720p@120fps)
- Network: 4G: LTE band 1/3/5/7/8/20/28/38/39/40/41 / 3G: 850/900/1900/2100 MHz / GSM: 850/900/1800/1900 MHz
- SIM card: Type: nano-SIM / Slot: Hybrid dual SIM (Optional: microSD)
- Wireless: Bluetooth: 4.2 / Wi-Fi: 802.11 a/b/g/n/ac, dual-band, 2.4 GHz & 5 GHz, DLNA, hotspot
- NFC: Yes
- Connection: USB Type-C 1.0 reversible connector
- Location: GPS, aGPS, Glonass, BeiDou
- Sensors: Ambient light sensor, eCompass, Fingerprint, Gyroscope, Magnetic sensor, Motion G-sensor, Proximity sensor, Sensor Hub
- Battery: 3000 mAh Built-in (non-removable) / Quick Charge 3.0
- Weight: 170 g
- Dimensions: 162.41 x 79.79 x 3.6-7.99 mm
- In the box: HTC U Ultra U-1u, HTC Rapid Charger 3.0, USB Type-C Cable, HTC Clear Case, HTC USonic™ Adaptive Earphones, Dust cloth, Sim tool