Doctor's Best - Biotin 10000 mcg. - 120 Vegetarian Capsules

UPC# :753950003736
Brand:Doctor's Best
Size/Form:120Vegetarian Capsules
Ship Weight:0.15
Servings:120
Dosage:1Capsule(s)

Doctor's Best - Biotin 10,000 mcg. - 120 Vegetarian Capsules
Doctor's Best Biotin 10,000 mcg. provides a substantial dose of the B-complex vitamin biotin, indispensable for the unique function of “biotinylation” that facilitates both energy and protein metabolism and healthy DNA activity. Clinical observations of biotin deficiency show its importance for the upkeep of healthy skin and hair, as well as for the immune and central nervous systems. Preliminary evidence also suggests that biotin can promote healthy nail renewal.
Best Biotin 10,000 mcg Benefits:Science-based nutritionDietary supplementPromotes healthy hair, skin, and nailsSupports gene regulation & DNA integritySupports essential enzyme functions
Promotes Healthy Hair, Skin and NailsConsiderable evidence links biotin status to the health of the hair, skin, and nails. One mutation is known that changes the structure of hair and makes it virtually impossible to comb. This is often accompanied by scaling of the scalp skin. Biotin supplementation was found to make such problem hair much easier to comb, while increasing the hair growth rate and eliminating scaling of the scalp.
Babies with inherited mutations of biotin enzymes, or simply with low blood biotin levels, can have totally bald scalps. Supplementation with biotin can restore hair growth in such bald babies, without adverse effects, and some researchers recommend that it be tried with any child having unexplained hair loss or skin changes.
Skin integrity is vulnerable to lack of biotin, whether due to its dietary insufficiency, poor absorption, or mutations in biotin enzymes. Biotin enzymes are involved in the metabolism of fatty acids, which are required for skin health, and this helps explain the link between biotin deficiency and skin changes. One indicator of biotin’s importance for the skin is that skin cells have transport proteins that are very efficient at importing biotin into the cell interior.
Clinical studies indicate biotin supplementation also can improve the nails. In a trial conducted with women, biotin (2.5 mg daily for 6-15 months) improved nail thickness by 25%, and also improved splitting of the nails. Microscopic examination revealed that the cell layer on the top of the nail also improved from an irregular to the more regular, normal orientation.
Supports Energy Generation and Other Essential Enzyme FunctionsAt least seven human enzymes require biotin in order to function. Five have biotin integrated within their structure as a coenzyme, and these all belong to the carboxylase category. Measuring the activities of these carboxylase enzymes gives a more accurate picture of the body’s biotin status than measuring blood biotin levels. The activity of each carboxylase enzyme can be conveniently assessed by measuring the level of its specific endproducta particular organic acidin the urine.
Of the five known biotin carboxylases, three are located in the mitochondria, the microscopic energy generators within our cells. Carboxylases that reside in the mitochondria help make heme, a protein that contains iron and is essential for the mitochondria’s energy generation functions. Consequently, biotin deficiency can impair the functioning of heme proteins in the mitochondria, which in turn can create a free radical challenge for the cell.
The sixth biotin enzyme is biotinidase, which functions to release biotin from its linkages to proteins or other biomolecules and thereby make it available for utilization as thecarboxylase coenzyme. Biotinidase also can remove biotin from used carboxylase molecules, for reuse in newly made carboxylase molecules. Mutations in biotinidase can markedly lower biotin absorption from the foods and contribute to depletion of the body’s biotin stores.
At least 165 biotinidase mutations are known to exist, and some countries routinely monitor newborns for the presence of such mutations. Supplementation with biotin (5-20 mg per day for 3-6 months) can correct some of the adverse effects associated with these mutations. Biotinidase also is involved in the use of biotin to help stabilize the DNA and regulate gene activity.
The seventh biotin enzyme is holocarboxylase synthetase (HS), which functions to attach biotin into all five of the biotin carboxylase enzymes. HS also works together with biotinidase to insert biotin into the gene structure. Mutations in HS are associated with an array of genic and metabolic abnormalities, some of which respond favorably to biotin supplementation.1
The seven biotin enzymes are so closely linked functionally, that a mutation which impairs any of them can potentially