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Pure Encapsulations - Nutrient 950 with Metafolin L-5-MTHF without Iron - 180 Vegetarian Capsules  |
| Pure Encapsulations - Nutrient 950 with Metafolin L-5-MTHF without Iron - 180 Vegetarian Capsules |
| 상품코드 : PROD120001841 |
| Pure Encapsulations - Nutrient 950 with Metafolin L-5-MTHF without Iron - 180 Vegetarian Capsules UPC# :766298002040 Brand:Pure Encapsulations Size/Form:180 ?Vegetarian Capsules Ship Weight:0.60 Servings:30 Dosage:6 ?Capsule(s)Click here to read a PDF brochure on this product Pure Encapsulations - Nutrient 950 with Metafolin L-5-MTHF without Iron - 180 Vegetarian Capsules Pure Encapsulations Nutrient 950 without Iron is now infused with Metafolin L-5-MTHF. Pure Encapsulations Nutrient 950 without Iron is a multi-vitamin/mineral formula for optimal health. Pure Encapsulations Nutrient 950 without Iron is a complete hypo-allergenic, high-nutrient, bioavailable multi-vitamin, multi-mineral and trace element supplement. Pure Encapsulations Nutrient 950 without Iron offers an advanced mineral delivery system, and the highly desirable coenzyme forms of B vitamins to promote optimal absorption of the nutrients. In addition, Pure Encapsulations Nutrient 950 without Iron provides a high profile of free radical scavenging antioxidants. Pure Encapsulations Nutrient 950 without Iron is a gentle, hypo-allergenic formula which is well tolerated by sensitive individuals. As part of a well-balanced diet that is low in saturated fat and cholesterol, folic acid, vitamin B6 and vitamin B12 may reduce the risk of vascular disease. Pure Encapsulations Nutrient 950 without Iron provides optimal nutritional support for all body systems. Pure Encapsulations Nutrient 950 without Iron is ideal for use by men and postmenopausal women. Optimizing folate delivery with Metafolin (L-5-MTHF)An extensive body of evidence indicates that adequate folate intake may provide significant cardiovascular, cellular and neural protection. However, genetic variations affecting activation and metabolism of supplemental folic acid are highly prevalent. In line with Pure Encapsulations" commitment to consistently offer innovative, science-based ingredients, Pure Encapsulations has updated a number of products, including their multivitamins, to provide Metafolin (L-5-MTHF). Metafolin is a naturally occurring, universally metabolized and active form of folate, L-5-MTHF. As such, it can be directly used in a diverse array of essential methylation reactions to support cardiovascular, neural and emotional health. Additionally, clinical evidence indicates that the bioavailability of Metafolin is superior to folic acid. In a double-blind, randomized, placebo controlled intervention study of 144 women of child-bearing age, 5-MTHF supplementation resulted in a greater accumulation of 5-MTHF in red blood cells than equimolar doses of folic acid. Metafolin For Optimal Folate Assimilation By Kelly C. Heim, Ph.D.Activation of folic acid and interconversion of reduced folate metabolites. DHF, dihydrofolate; DHFR, dihydrofolate reductase; THF, tetrahydrofolate reductase; MTHFR, methyltetrahydrofolate reductase; 5-MTHF, methyltetrahydrofolate; SAMe, S-adenosylmethionine; SAH, S-adenosylhomocysteine; dUMP; deoxyuridine monophosphate; dTMP, deoxythymidine monophosphate. Folate is a general term referring to folic acid (pteroylglutamic acid) and its reduced derivatives. Reduced, or activated folate is the coenzyme that participates in numerous methylation reactions, which include biosynthesis of nucleic acids, neuronal membrane components and neurotransmitters. Importantly, methylation of chromatin and DNA by reduced folate is an important aspect of the maintenance of healthy gene expression. Folic acid is a synthetic, oxidized folate that requires enzymatic reduction in order to function as a methyl donor. Reductive activation of folic acid is a multi-step process. Recent evidence indicates that the efficiency of this conversion may be low and variable, possibly explaining the high plasma levels of oxidized folic acid observed in subjects receiving supplemental folic acid. The long-term effects of sustained tissue exposure to oxidized folic acid are unknown. In food, folate naturally occurs primarily in the activated form, (L)-5-methyl-THF (5-MTHF). While synthetic folic acid can be converted to 5-MTHF in the body, this process requires the enzyme 5,10-methylene tetrahydrofolate reductase (MTHFR). Highly prevalent genetic variations in MTHFR compromise the efficiency of 5-MTHF synthesis. MTHFR comprises a pivotal node in folate biochemistry, transferring methyl groups to maintain essential biosynthetic and genomic regulatory processes. Metafolin ((L)-5-MTHF) is stereochemically identical to naturally occurring 5-MTHF. Metafolin does not require modification and can therefore execute the beneficial effects of folate regardless of MTHFR genotype. Metafolin is also efficiently absorbed and assimilated. In a double-blind, randomized, placebo-controlled intervention study of 144 women, 5-MTHF supplementation resulted in a grea |