Non-Nano & not micronized; means the particles are large enough to sit on the skin & achieve their purpose (sunblock, reduce acne and rashes, soothe redness, etc.) instead of being absorbed into the blood stream. Pharmaceutical Grade means free of lead, mercury and metals; Can be added to creams & lotions to add sun protection. Best broad spectrum UVA & UVB reflector approved for use as a sunscreen by FDA..