Acetyl hexapeptide-3 is a synthetic anti-wrinkle cosmetics ingredient also it is a peptide marketed as Argireline which is used in attempts to decrease the visible effects of aging by reducing the deep wrinkles and lines that occur around the forehead and eyes. Argireline has remarkable and long-lasting antiwrinkle activity but not neurotoxicity. Unlike the Botulinum neurotoxins (BoNTs) it represent a revolution in cosmetic science.</br>The biologically active form from vitamin E is ?-tocopherol it is an important lipid-soluble antioxidant. It performs its functions as antioxidant in the glutathione peroxidase pathway and it protects cell membranes from oxidation by reacting with lipid radicals produced in the lipid peroxidation chain reaction. As an antioxidant vitamin E acts as a peroxyl radical scavenger disabling the production of damaging free radicals in tissues. It plays a role in revive the cell from been damaged.</br>Allantoin as an active ingredient in over-the-counter cosmetics has several beneficial effects including: a moisturizing and keratolytic effect increasing the water content of the extracellular matrix and enhancing the desquamation of upper layers of dead skin cells?? increasing the smoothness of the skin; promoting cell proliferation and wound healing; and a soothing?? anti-irritant?? and skin protectant effect by forming complexes with irr